Molecular and biological functions of resveratrol in psychiatric disorders: a review of recent evidence

Cell & Bioscience

Table 2 Animal studies that investigated the therapeutic effects of resveratrol on anxiety

Disease	Dose of resveratrol	Model	Findings	Publish year	Refs.
PTSD-induced anxiety	10, 20 and 40 mg/kg	In vivo	Alleviate L-HPA axis, corticotrophin-releasing factor levels, and glucocorticoid receptor in the hypothalamus, hippocampus, and amygdala, increased pCREB and BDNF	2018	[108]
PTSD-induced anxiety	40 mg/kg	In vivo	Alleviate L-HPA axis, elevated protein kinase A, phosphorylated CREB protein, and BDNF	2020	[109]
Anxiety	200 and 400 mg/kg	In vivo	Anxiolysis and anti-psychotic effects	2017	[119]
Ovariectomy-induced anxiety	20 mg/kg	In vivo	Decreased anxiety-like behaviors, decreased activation of microglia in the hippocampal dentate gyrus, hippocampal levels of NLRP3, and NF-kB, inhibited cytokine production, increased Sirt1 concentrations	2019	[85]
Diabetes-induced anxiety	10 mg/kg/day	In vivo	Increased Sirt1 and Sirt7	2016	[118]
Anxiety	1 and 2 mg/kg	In vivo	Anxiolytic function	2013	[120]

ISSN: 2045-3701