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Table 1 The sequences of SARS-CoV-2 used for interaction analysis

From: Genome-wide analysis of protein–protein interactions and involvement of viral proteins in SARS-CoV-2 replication

Protein Coding sequence* Position in polyprotein* Protein length Function described**
Nsp1 266–805 M1-G180 180 Inhibits host gene expression
Nsp2 806–2719 A181-G818 638  
Nsp3.1 2720–4966 A819-T1568 749 ADRP, SUD for OGB
Nsp3.2 4967–7105 I1569-T2282 713 PLpro, DU
Nsp3.3 7106–8554 Y2283-G2765 483  
Nsp4 8555–10054 K2766-Q3266 500 Membrane rearrangement, essential for viral replication
Nsp5 10055–10972 S3267-Q3572 306 3C-like proteinase
Nsp6 10973–11842 S3573-Q3863 290 TM
Nsp7 11843–12091 S3864-Q3945 81 dsRNA-binding
Nsp8 12092–12685 A3946-Q4144 198 dsRNA-binding & RdRP
Nsp9 12686–13024 N4145-Q4258 113 ssRNA-binding
Nsp10 13025–13441 A4259-Q4398 139 GFL
Nsp12 13442–16236 S4399-Q5331 932 RdRP
Nsp13 16237–18039 A5332-Q5933 601 The helicase enzyme, NTPase
Nsp14 18040–19620 A5934-Q6461 527 ExoN
Nsp15 19621–20658 S6462-Q6808 346 EndoRNase, degrades viral dsRNA
Nsp16 20659–21552 S6809-N7107 298 2ʹ-O-MT
S1 21563–23617 n/a 685 Spike (receptor-binding)
S2 23618–25384 n/a 588 Spike (fusion peptide & TM)
3 25393–26220 n/a 275 TM, ion channel, antagonist of IFN
E 26245–26472 n/a 75 envelope
M 26523–27191 n/a 222 Membrane
6 27202–27387 n/a 61 Viral pathogenesis
7a 27394–27759 n/a 121  
7b 27756–27884 n/a 43  
8 27894–28259 n/a 121 Disrupts antigen presentation
N 28274–29533 n/a 419 Binds viral RNA, antagonize antiviral RNAi
10 29558–29674 n/a 38  
  1. n/a not applied
  2. *The coordinate of the sequence is based on the genome of severe acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1 (NCBI Reference Sequence: NC_045512.2)
  3. **Abbreviations: ADRP adenosine diphosphate-ribose 1”-phosphatase, SUD SARS Unique Domain, OGB oligo(G)-binding, PLpro papain-like cysteine proteinase, DU deubiquitinating activity, TM transmembrane domain, RdRP RNA-dependent RNA polymerase, GFL growth-factor-like protein, NTPase NTP and RNA 5’ triphosphatase, ExoN 3’ to 5’ exonuclease, 2’-O-MT S-adenosylmethionine-dependent ribose 2’-O-methyltransferase, IFN interferon
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Cell & Bioscience

ISSN: 2045-3701

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